cardioprotective effect of aqueous extract of chichorium intybus l. on ischemia-reperfusion injury in isolated rat heart

نویسندگان

najmeh sadeghi department of physiology, faculty of medicine, jahrom university of medical sciences, jahrom, iran

mahin dianat physiology research center, department of physiology, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran

mohammad badavi physiology research center, department of physiology, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran

ahad malekzadeh department of statistic, khajeh nasir toosi university of technology, tehran, iran

چکیده

objective: several studies have shown that chichorium intybus l. (c. intybus) which possesses flavonoid compounds has an effective role in treatment of cardiovascular diseases. contractile dysfunction mostly occurs after acute myocardial infarction, cardiac bypass surgery, heart transplantation and coronary angioplasty. the aim of the present study was to investigate the effect of aqueous extract of c. intybus on ischemia- reperfusion injury in isolated rat heart. materials and methods: the animals were divided into four groups (sham, control, 1 mg/ml and 3 mg/ml of extract) of 8 rats. the aorta was cannulated, and then the heart was mounted on a langendorff apparatus. next, a balloon was inserted into the left ventricle (lv) and peak positive value of time derivate of lv pressure (+dp/dt), coronary flow (cf), and left ventricular systolic pressure (lvsp) in pre-ischemia and reperfusion period were calculated by a power lab system. all groups underwent a 30-minute global ischemia followed by a 60-minute reperfusion. results: the results showed that heart rate (hr), coronary flow, and left ventricular developed pressure (lvdp) and rate of pressure product (rpp) significantly decreased in the control group during reperfusion, while these values in the groups receiving the extract (3mg/ml) improved significantly during reperfusion (p<0.001). conclusion: it seems that flavonoid compounds of aqueous extract of c. intybus reduce ischemia - reperfusion injuries, suggesting its protective effect on heart function after ischemia.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Cardioprotective effect of aqueous extract of Chichorium intybus on ischemia-reperfusion injury in isolated rat heart.

OBJECTIVE Several studies have shown that Chichorium intybus (C. intybus) which possesses flavonoid compounds has an effective role in treatment of cardiovascular diseases. Contractile dysfunction mostly occurs after acute myocardial infarction, cardiac bypass surgery, heart transplantation and coronary angioplasty. The aim of the present study was to investigate the effect of aqueous extract o...

متن کامل

Cardioprotective effect of aqueous extract of Chichorium intybus L. on ischemia-reperfusion injury in isolated rat heart

Objective: Several studies have shown that Chichorium intybus L. (C. intybus) which possesses flavonoid compounds has an effective role in treatment of cardiovascular diseases. Contractile dysfunction mostly occurs after acute myocardial infarction, cardiac bypass surgery, heart transplantation and coronary angioplasty. The aim of the present study was to investigate the effect of aqueous extra...

متن کامل

Cardioprotective Effect of Garlic Juice on the Isolated Rat Heart in Ischemia- Reperfusion

Background: It has been reported that the chronic oral administration of garlic homogenate protected the rat heart from in vitro ischemic reperfusion injury. However, the biological effects of garlic juice on the heart are expected to be different from oral administration of it. Objective: the present study was designed to investigate the effect of garlic juice on the isolated rat heart in is...

متن کامل

Cardioprotective effects of methanolic extract of Scrophularia frigida on ischemia-reperfusion-induced injuries in isolated rat heart

Myocardial infarction is a common presentation of coronary artery disease and the leading cause of death worldwide. The present study was investigated potential resistance to ischemia-reperfusion (I/R) injuries following administration of methanolic (MeOH) extract of Scrophularia frigida (S. frigida) in isolated rat heart. Male Wistar rat hearts (n= 8-10) were isolated and allowed to equilibrat...

متن کامل

Cardioprotective effects of methanolic extract of Scrophularia frigida on ischemia-reperfusion-induced injuries in isolated rat heart

Myocardial infarction is a common presentation of coronary artery disease and the leading cause of death worldwide. The present study was investigated potential resistance to ischemia-reperfusion (I/R) injuries following administration of methanolic (MeOH) extract of Scrophularia frigida (S. frigida) in isolated rat heart. Male Wistar rat hearts (n= 8-10) were isolated and allowed to equilibrat...

متن کامل

Cardioprotective effects of bilberry extract on ischemia-reperfusion-induced injury in isolated rat heart

Methods Anthocyanins from the prepared bilberry extract were analyzed using the HPLC-DAD system and were expressed as a standard of cyanidine-3-glucoside (mg/L). Experiments were carried out on the isolated hearts from Wistar rats of both sexes according to the Langendorff method. Postischemic myocardial injuries during reperfusion were determined by changes in coronary flow rate, lactate dehyd...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
avicenna journal of phytomedicine

جلد ۵، شماره ۶، صفحات ۵۶۸-۵۷۵

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023